RNA-Sick

生物資訊 の 冒險記趣 — a 14-day introduction to RNA-seq analysis

A 14-part tutorial series I wrote in 2019 for the 11th iThome Ironman challenge, aimed at biology students meeting the command line for the first time. It walks from “why bioinformatics” all the way to a differential-expression result — terminal, Anaconda, Python, fetching SRA data, QC, assembly, annotation, alignment, quantification, and edgeR.

The series is written in Traditional Chinese. These 14 days are the core RNA-seq pipeline, archived here from my older site. The code and tools date to 2019, so treat versions and commands as historical. The original was a 30-day run for the iThome Ironman challenge — the remaining days live on the original iThome series.

  1. Day 1 成為賽博格研究生:生物資訊導論
  2. Day 2 終端機操作 Terminal
  3. Day 3 套件管理 Anaconda
  4. Day 4 Python 入門
  5. Day 5 文字編輯器 Vim
  6. Day 6 下載定序資料 SRA(上)
  7. Day 7 下載定序資料 SRA(下)
  8. Day 8 品質檢查 FastQC
  9. Day 9 品質修剪 Trimmomatic
  10. Day 10 轉錄體組裝 Trinity
  11. Day 11 功能註釋 Trinotate
  12. Day 12 序列比對 Bowtie2
  13. Day 13 表現量定量 kallisto
  14. Day 14 差異表現分析 edgeR